During the proliferation phase, which process describes the role of epithelial tissue?

• A. It forms granulation tissue
• B. It contracts the wound edges
• C. It covers the wound bed after granulation tissue has formed
• D. It destroys collagen

Answer: (C)

During the proliferation phase, epithelial tissue’s job is to re-epithelialize the wound by migrating across the underlying granulation tissue to form a new, continuous epidermal layer. Epithelial cells move in from the wound margins (and from any remaining epidermal structures) once a vascularized granulation bed is established, sealing the surface to restore the skin’s barrier. This re-epithelialization reduces fluid loss and lowers infection risk, helping the wound achieve a stable, protective cover. Wound contraction is driven by other cells (myofibroblasts) and serves to shrink the wound, while collagen laid down during proliferation is later remodeled. Epithelial tissue doesn’t destroy collagen.