Which of the following is NOT listed as a common adverse effect of opioid analgesics?

• A. Sedation
• B. Respiratory depression
• C. Constipation
• D. Hypertension

Answer: (D)

Opioid analgesics commonly cause sedation, respiratory depression, and constipation because they depress the central nervous system and slow gut motility. Hypertension is not a typical adverse effect of opioid therapy; these drugs more often cause hypotension or vasodilation rather than high blood pressure. So hypertension would not be expected as a common adverse effect. In practice, monitor respiratory status and level of consciousness, and implement strategies to prevent or treat constipation, while being cautious with other CNS depressants and in populations at higher risk for sedation.